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2023•PubMedRequires access

[Genetics of brain networks].

Bernardo de A.P.C. Maciel, Koen Helwegen, Martijn P. van den Heuvel

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Abstract

BACKGROUND: Genetic analyses reveal multiple genes and pathways that are involved in brain networks. Similarly, for psychiatric disorders several genes and reliable changes in brain features have been found, raising the question of the relationship between the two. AIM: To explore the genetics of brain networks in relation to mental health. METHOD: Review of selected literature on the genetics of brain networks in the context of common psychiatric phenotypes. RESULTS: Well-defined genetic conditions allow us to infer the relationship between brain networks and symptoms. In complex traits where many genes have an effect, genome-wide association studies can help us interrogate their genetics. CONCLUSION: The combination of neuroimaging and genetics data opens new possibilities to map the biological processes that underpin behaviour, mental health and psychiatric conditions.

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What this paper is about

BACKGROUND: Genetic analyses reveal multiple genes and pathways that are involved in brain networks. Similarly, for psychiatric disorders several genes and reliable changes in brain features have been found, raising the question of the relationship between the two. AIM: To explore the genetics of brain networks in relation to mental health. METHOD: Review of selected literature on the genetics of brain networks in the context of common psychiatric phenotypes. RESULTS: Well-defined genetic conditions allow us to infer the relationship between brain networks and symptoms. In complex traits where many genes have an effect, genome-wide association studies can help us interrogate their genetics. CONCLUSION: The combination of neuroimaging and genetics data opens new possibilities to map the biological processes that underpin behaviour, mental health and psychiatric conditions.

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Available abstract

BACKGROUND: Genetic analyses reveal multiple genes and pathways that are involved in brain networks. Similarly, for psychiatric disorders several genes and reliable changes in brain features have been found, raising the question of the relationship between the two. AIM: To explore the genetics of brain networks in relation to mental health. METHOD: Review of selected literature on the genetics of brain networks in the context of common psychiatric phenotypes. RESULTS: Well-defined genetic conditions allow us to infer the relationship between brain networks and symptoms. In complex traits where many genes have an effect, genome-wide association studies can help us interrogate their genetics. CONCLUSION: The combination of neuroimaging and genetics data opens new possibilities to map the biological processes that underpin behaviour, mental health and psychiatric conditions.

Key concepts: Imaging genetics, Psychiatric genetics, Neuroimaging, Genome-wide association study, Context (archaeology), Genetic association, Mental health, Phenotype

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