2023•Advanced ScienceOpen access

Highly‐Specific Single‐Stranded Oligonucleotides and Functional Nanoprobes for Clinical Determination of Chlamydia Trachomatis and Neisseria Gonorrhoeae Infections (Adv. Sci. 36/2023)

Ketan Dighe, Parikshit Moitra, Nivetha Gunaseelan, Maha Alafeef, Tor Jensen, Carla Rafferty, Dipanjan Pan

Abstract

Clinical Determination of Chlamydia Trachomatis and Neisseria Gonorrhoeae Infections In article number 23004009 by Dipanjan Pan and co-workers, novel single-stranded DNA (ssDNA) probes are designed to target genetic segments of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). These probes are then attached to gold nanoparticles (AuNPs) to create an absorbance-based assay. The assay relies on complementary binding between the probes and the target gene sequences unique to CT or NG. The method is validated with clinical samples, achieving high sensitivity and specificity.

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Key concepts: Chlamydia trachomatis, Neisseria gonorrhoeae, Oligonucleotide, Neisseria, Chlamydia, Microbiology, Absorbance, Virology