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2023•EJC Paediatric OncologyOpen access

ACCELERATED CLEARANCE OF ANTI-THYMOCYTE GLOBULIN IN CHILDREN TRANSPLANTED FOR REFRACTORY CYTOPENIA OF CHILDHOOD VERSUS APLASTIC ANEMIA IS ASSOCIATED WITH INCREASED RISK OF GVHD

Eva Koopman-Coenen, Joyce Meesters-Ensing, Stefan Nierkens, Ireen J. Kal, Konradin F. Müskens, Birgitta A. B. Versluys, Caroline A. Lindemans, Marc Bierings, Rick Admiraal, Mirjam E. Belderbos

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Abstract

Background and aims: Myelodysplastic syndrome–refractory cytopenia of childhood (MDS-RCC) and severe aplastic anemia (SAA) are two forms of pediatric bone marrow failure that share similar clinical features but have different pathophysiology. Hematopoietic cell transplantation (HCT) is a curative therapy for both conditions. While the outcome of HCT for SAA is excellent, there is limited knowledge on the outcome of HCT for MDS-RCC. This study aims to compare HCT outcomes for MDS-RCC and SAA and explore the impact of anti-thymocyte globulin (ATG) exposure on these outcomes.

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Background and aims: Myelodysplastic syndrome–refractory cytopenia of childhood (MDS-RCC) and severe aplastic anemia (SAA) are two forms of pediatric bone marrow failure that share similar clinical features but have different pathophysiology. Hematopoietic cell transplantation (HCT) is a curative therapy for both conditions. While the outcome of HCT for SAA is excellent, there is limited knowledge on the outcome of HCT for MDS-RCC. This study aims to compare HCT outcomes for MDS-RCC and SAA and explore the impact of anti-thymocyte globulin (ATG) exposure on these outcomes.

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Available abstract

Background and aims: Myelodysplastic syndrome–refractory cytopenia of childhood (MDS-RCC) and severe aplastic anemia (SAA) are two forms of pediatric bone marrow failure that share similar clinical features but have different pathophysiology. Hematopoietic cell transplantation (HCT) is a curative therapy for both conditions. While the outcome of HCT for SAA is excellent, there is limited knowledge on the outcome of HCT for MDS-RCC. This study aims to compare HCT outcomes for MDS-RCC and SAA and explore the impact of anti-thymocyte globulin (ATG) exposure on these outcomes.

Key concepts: Anti-thymocyte globulin, Cytopenia, Aplastic anemia, Medicine, Refractory (planetary science), Globulin, Immunology, Refractory anemia

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ACCELERATED CLEARANCE OF ANTI-THYMOCYTE GLOBULIN IN CHILDREN TRANSPLANTED FOR REFRACTORY CYTOPENIA OF CHILDHOOD VERSUS APLASTIC ANEMIA IS ASSOCIATED WITH INCREASED RISK OF GVHD — Research Paper | ScholarLens