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2023•RSC Medicinal ChemistryOpen access

Impact of dipeptide on ADC physicochemical properties and efficacy identifies Ala–Ala as the optimal dipeptide

Lu Wang, Adrian D. Hobson, Julia Fitzgibbons, Axel Hernández, Ying Jia, Zhou Xu, Zhongyuan Wang, Yajie Yu, Xiang Li

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Abstract

A glucocorticoid receptor modulator (GRM) was conjugated to a mouse anti-TNF antibody using various dipeptide linkers. Impact of dipeptide linkers on ADC physical properties, including solubility, hydrophobicity, and aggregation were evaluated.

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A glucocorticoid receptor modulator (GRM) was conjugated to a mouse anti-TNF antibody using various dipeptide linkers. Impact of dipeptide linkers on ADC physical properties, including solubility, hydrophobicity, and aggregation were evaluated.

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Available abstract

A glucocorticoid receptor modulator (GRM) was conjugated to a mouse anti-TNF antibody using various dipeptide linkers. Impact of dipeptide linkers on ADC physical properties, including solubility, hydrophobicity, and aggregation were evaluated.

Key concepts: Dipeptide, Linker, In silico, Chemistry, Combinatorial chemistry, Amino acid, Conjugated system, Oligopeptide

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