2023•Unpublished venueRequires access

STIMULATION OF HUMAN DERMAL FIBROBLASTS CHONDROGENIC DIFFERENTIATION FOR TISSUE ENGINEERING OF HYALINE CARTILAGE

Д. М. Марченко, M. S. Bozhokin, Elena Mikhailova, Julia V. Sopova, Mikhail Khotin

Abstract

This work is devoted to the possibility of human dermal fibroblasts chondrogenic differentiation using the TGF-β3 and SOX9 recombinant proteins and lentiviral vectors carrying sequences of the Tgf-β3 and Sox9 genes. It has been shown that the use of the TGF-β3 protein and vector with the Sox9 gene makes it possible to increase the expression of associated with chondrogenesis genes in fibroblasts.

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Available abstract

Key concepts: SOX9, Chondrogenesis, Cell biology, Recombinant DNA, Cartilage, Tissue engineering, Transforming growth factor, Hyaline cartilage