ScholarLens Back to search
1995•Unpublished venueRequires access

Tumour Necrosis Factor-P

Isabelle Millet, NoreenL Rudd

Open publisher page 0 citations

Abstract

Abstract Tumor necrosis factor-/] is also known as lymphotoxin, lymphotoxin-a, and cytotoxic factor. TNF/J is closely related and genetically linked to TNFa (Turetskaya et al. 1992) and LT/J (Browning et al. 1993). It has many of the same activities as TNFa. It is also related to CD40 ligand, CD27 ligand, and CD30 ligand. In contrast to the other family members it does not possess a transmembrane leader peptide and it is secreted. However, it can form a heteromeric membrane associated complex with LT/J (Fig. 1). TNF/J binds with high affinity to two different receptors, p55 TNF receptor and p75 TNF receptor.

About this research paper

What this paper is about

Abstract Tumor necrosis factor-/] is also known as lymphotoxin, lymphotoxin-a, and cytotoxic factor. TNF/J is closely related and genetically linked to TNFa (Turetskaya et al. 1992) and LT/J (Browning et al. 1993). It has many of the same activities as TNFa. It is also related to CD40 ligand, CD27 ligand, and CD30 ligand. In contrast to the other family members it does not possess a transmembrane leader peptide and it is secreted. However, it can form a heteromeric membrane associated complex with LT/J (Fig. 1). TNF/J binds with high affinity to two different receptors, p55 TNF receptor and p75 TNF receptor.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Abstract Tumor necrosis factor-/] is also known as lymphotoxin, lymphotoxin-a, and cytotoxic factor. TNF/J is closely related and genetically linked to TNFa (Turetskaya et al. 1992) and LT/J (Browning et al. 1993). It has many of the same activities as TNFa. It is also related to CD40 ligand, CD27 ligand, and CD30 ligand. In contrast to the other family members it does not possess a transmembrane leader peptide and it is secreted. However, it can form a heteromeric membrane associated complex with LT/J (Fig. 1). TNF/J binds with high affinity to two different receptors, p55 TNF receptor and p75 TNF receptor.

Key concepts: Lymphotoxin, Lymphotoxin beta receptor, Tumor necrosis factor alpha, Lymphotoxin alpha, Receptor, Transmembrane protein, Ligand (biochemistry), Tumor necrosis factor receptor

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Tumour Necrosis Factor-P — Research Paper | ScholarLens