Proto–Neurons from Abiotic Polypeptides

Understanding the origins of life involves dealing with the unresolved question of how the first informational polymers and cell-like structures emerged from prebiotic chemistry. The formation of thermal proteinoids through the heating of mixtures of amino acids, leading to the spontaneous formation of protocells enclosed by membranes, presents a compelling model for the synthesis of polypeptides in an abiogenic context. Recent research has revealed the presence of electrical excitability and signal processing capacities in proteinoids, indicating the possibility of primitive cognitive functions and problem-solving capabilities. The present study provides a comprehensive examination of the features shown by heat proteinoids and their potential significance in the context of the artificial formation of polypeptides during the early stages of Earth’s development. Experiments showcasing the possibility for unconventional computing with proteinoids as well as modelling proteinoid assemblies into synthetic proto-brains are given. Proteinoids’ robust abiogenic production, biomimetic features, and computational capability shed light on potential phases in the evolution of polypeptides and primitive life from the primordial environment.