2023•Stem Cell ReportsOpen access

Is epigenome editing non-inheritable? Implications for ethics and the regulation of human applications

Mitsuru Sasaki‐Honda, Kyoko Akatsuka, Tsutomu Sawai

Abstract

Epigenome editing offers ethical advantages with non-inheritable gene expression control. However, concerns arise regarding potential transgenerational effects in humans. Ethical and regulatory evaluation is crucial, considering recent advancements and enhanced understanding of transgenerational epigenetics in both mammals and humans.

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Available abstract

Key concepts: Epigenome, Transgenerational epigenetics, Biology, Epigenetics, Genome editing, Computational biology, Genetics, Engineering ethics