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2023•Yearbook of pediatric endocrinologyRequires access

Effect of initial levothyroxine dose on neurodevelopmental and growth outcomes in children with congenital hypothyroidism

Andrea Esposito, Vigone MC, Miriam Polizzi, Wasniewska MG, Alessandra Cassio, Alessandro Mussa, Roberto Gastaldi, Di Mase R, G Vincenzi, Clara Pozzi, Elena Peroni, Carmela Bravaccio, Donatella Capalbo, Dario Bruzzese, Mariacarolina Salerno

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Abstract

Brief summary: Current guidelines for congenital hypothyroidism recommend a starting dose of 10–15 μg/d of levothyroxine for optimal treatment (1). Over the last years, some studies suggested that overtreatment of patients during infancy by high levothyroxine doses might have negative effects on neurocognitive and behavioral development (2). The presented multicenter prospective randomized trial aimed at comparing the effect of higher (12.5–15.0 μg/d levothyroxine starting dose) versus lower (10.0–12.5 μg/d levothyroxine starting dose) on growth and neurocognitive outcome.

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What this paper is about

Brief summary: Current guidelines for congenital hypothyroidism recommend a starting dose of 10–15 μg/d of levothyroxine for optimal treatment (1). Over the last years, some studies suggested that overtreatment of patients during infancy by high levothyroxine doses might have negative effects on neurocognitive and behavioral development (2). The presented multicenter prospective randomized trial aimed at comparing the effect of higher (12.5–15.0 μg/d levothyroxine starting dose) versus lower (10.0–12.5 μg/d levothyroxine starting dose) on growth and neurocognitive outcome.

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Available abstract

Brief summary: Current guidelines for congenital hypothyroidism recommend a starting dose of 10–15 μg/d of levothyroxine for optimal treatment (1). Over the last years, some studies suggested that overtreatment of patients during infancy by high levothyroxine doses might have negative effects on neurocognitive and behavioral development (2). The presented multicenter prospective randomized trial aimed at comparing the effect of higher (12.5–15.0 μg/d levothyroxine starting dose) versus lower (10.0–12.5 μg/d levothyroxine starting dose) on growth and neurocognitive outcome.

Key concepts: Levothyroxine, Congenital hypothyroidism, Pediatrics, Medicine, Endocrinology, Internal medicine, Hormone, Thyroid

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Effect of initial levothyroxine dose on neurodevelopmental and growth outcomes in children with congenital hypothyroidism — Research Paper | ScholarLens