2023•PubMedRequires access

[Research Advances on Strategies to Promote Homing and Engraftment of Hematopoietic Stem Cells--Review].

Pingping Zhu, Ruiting Wen, Zhigang Yang

Abstract

The homing and engraftment of hematopoietic stem cells (HSC) into bone marrow is the first critical step for successful clinical hematopoietic stem cell transplantation (HSCT). SDF-1 / CXCR4 is considered to be a very promising target to promote HSC homing. In recent years, with the in-depth research on the HSC homing, a variety of new strategies for promoting HSC homing and engraftment have been explored, such as nuclear hormone receptor, histone deacetylase inhibitor, prostaglandin and metabolic regulation, so as to increase the success rate of HSCT and improve the survival of patients. In this review, the recent research advances in the mechanism of HSC homing and strategies to promote HSC homing and engraftment were summarized and discussed.

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Key concepts: Homing (biology), CXCR4, Stem cell, Hematopoietic stem cell, Haematopoiesis, Hematopoietic stem cell transplantation, Bone marrow, Cancer research