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De novo mTOR inhibitor immunosuppression versus calcineurin inhibitor immunosuppression for liver transplant recipients

Sophie Kollbeck, Julia‐Kristin Graß, Jens Hillingsø, Luit Penninga

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Abstract

Objectives This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of de novo mTOR inhibitor‐based versus calcineurin inhibitor‐based immunosuppression for liver transplant recipients.

About this research paper

What this paper is about

Objectives This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of de novo mTOR inhibitor‐based versus calcineurin inhibitor‐based immunosuppression for liver transplant recipients.

Why it matters

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Key contribution

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Method / approach

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Main findings

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Limitations

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Available abstract

Objectives This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of de novo mTOR inhibitor‐based versus calcineurin inhibitor‐based immunosuppression for liver transplant recipients.

Key concepts: Immunosuppression, Calcineurin, Discovery and development of mTOR inhibitors, Medicine, Liver transplantation, Sirolimus, PI3K/AKT/mTOR pathway, Tacrolimus

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