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2023•Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and ExhibitionRequires access

Quantitative Evaluation of Substantia Nigra Degeneration in Parkinson’s Disease using T1 mapping

Ayaka Yokota, Yasuhiro Fujiwara, Tetsuyoshi Hirai, Nobutaka Sakae, Naokazu Sasagasako, Takahisa Izumi, Kuniharu Ohi, Hiroyuki Kumazoe

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Abstract

We evaluated the T1 values of the whole and subregions of the substantia nigra (SN) in patients with Parkinson's disease (PD) to identify an imaging biomarker for the early diagnosis of PD. T1 values of the SN of patients with PD were significantly shorter than those of healthy controls and tended to be longer in the lateral part for both groups. T1 values may reflect the pathology of the SN and help assess the degeneration of the SN caused by PD.

About this research paper

What this paper is about

We evaluated the T1 values of the whole and subregions of the substantia nigra (SN) in patients with Parkinson's disease (PD) to identify an imaging biomarker for the early diagnosis of PD. T1 values of the SN of patients with PD were significantly shorter than those of healthy controls and tended to be longer in the lateral part for both groups. T1 values may reflect the pathology of the SN and help assess the degeneration of the SN caused by PD.

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Method / approach

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Available abstract

We evaluated the T1 values of the whole and subregions of the substantia nigra (SN) in patients with Parkinson's disease (PD) to identify an imaging biomarker for the early diagnosis of PD. T1 values of the SN of patients with PD were significantly shorter than those of healthy controls and tended to be longer in the lateral part for both groups. T1 values may reflect the pathology of the SN and help assess the degeneration of the SN caused by PD.

Key concepts: Substantia nigra, Parkinson's disease, Degeneration (medical), Biomarker, Disease, Pathology, Medicine, Degenerative disease

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