DEVELOPMENT AND EVALUATION OF KETOCONAZOLE DRUG LOADED TRANSDERMAL PATCHES FOR ANTIFUNGAL ACTION

Ketoconazole is an antibiotic used to treat certain infections caused by bacteria, such as pneumonia, bronchitis, ear infection, sinusitis, pharyngitis, tonsillitis, and skin fungal infections.In this study, Ketoconazole was used to prepare transdermal patches using various polymers such as Hydroxy Propyl Methyl Cellulose, Ethyl Cellulose, Glycerine and Dimethyl Sulfoxide with their different concentration.Patches were prepared by the solvent Casting technique.Dimethyl sulphoxide was used to enhance the transdermal permeation of ketoconazole.Formulated transdermal films were physically evaluated with regard to thickness, weight variation, drug content, flatness, tensile strength, folding endurance and percentage of moisture content.All prepared formulations indicated good physical stability.