2023Chemical ScienceOpen access

2,5-disubstituted bicyclo[2.1.1]hexanes as rigidified cyclopentane variants

Shashwati Paul, Daniel Adelfinsky, Christophe Salomé, Thomas C. Fessard, M. Kevin Brown

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Abstract

-1,3-disubstituted cyclopentanes, common motifs in drugs. The scalable synthesis of these structures was enabled through the use of C-H functionalization logic and cycloaddition reactions.

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-1,3-disubstituted cyclopentanes, common motifs in drugs. The scalable synthesis of these structures was enabled through the use of C-H functionalization logic and cycloaddition reactions.

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Available abstract

-1,3-disubstituted cyclopentanes, common motifs in drugs. The scalable synthesis of these structures was enabled through the use of C-H functionalization logic and cycloaddition reactions.

Key concepts: Cyclopentane, Bicyclic molecule, Chemistry, Stereochemistry

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