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2023•Current Opinion in Infectious DiseasesRequires access

Neutropenia and antibiotics: when, what, how and why?

Jana Dickter, Cathy Logan, Randy Taplitz

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Abstract

PURPOSE OF REVIEW: Our aim is to review recent literature on antibiotic use in patients with neutropenia. RECENT FINDINGS: Prophylactic antibiotics are associated with risks and have limited mortality benefit. While early antibiotic use in febrile neutropenia (FN) is critical, early de-escalation or discontinuation may be safe in many patients. SUMMARY: With an increasing understanding of potential risks and benefits of use and improved risk assessment, paradigms of antibiotic use in neutropenic patients are changing.

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What this paper is about

PURPOSE OF REVIEW: Our aim is to review recent literature on antibiotic use in patients with neutropenia. RECENT FINDINGS: Prophylactic antibiotics are associated with risks and have limited mortality benefit. While early antibiotic use in febrile neutropenia (FN) is critical, early de-escalation or discontinuation may be safe in many patients. SUMMARY: With an increasing understanding of potential risks and benefits of use and improved risk assessment, paradigms of antibiotic use in neutropenic patients are changing.

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OpenAlex reports 9 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

PURPOSE OF REVIEW: Our aim is to review recent literature on antibiotic use in patients with neutropenia. RECENT FINDINGS: Prophylactic antibiotics are associated with risks and have limited mortality benefit. While early antibiotic use in febrile neutropenia (FN) is critical, early de-escalation or discontinuation may be safe in many patients. SUMMARY: With an increasing understanding of potential risks and benefits of use and improved risk assessment, paradigms of antibiotic use in neutropenic patients are changing.

Key concepts: Medicine, Discontinuation, Antibiotics, Intensive care medicine, Neutropenia, Febrile neutropenia, Internal medicine, Chemotherapy

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