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2023•Clinical pharmacology and therapyOpen access

Targeted treatment challenges in patients with adult-onset Still’s disease

A. I. Zavrazhnova, E. S. Kuvardin, Valentina Yu. Myachikova, A. Khadgidis, Natalia A Anokhina, M. Anriyanova, Ya. I. Kozlova, A. L. Maslyanskiy

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Abstract

Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disease mediated by interleukin (IL)-1 production. There are no treatment guidelines for AOSD due to its rarity and heterogenous manifestations. Therefore, each case is challenging and requires a multidisciplinary approach. We report a case of AOSD occurring in pregnant patient who did not respond to standard treatment with glucocorticoids and developed skin reaction to IL-1 receptor antagonist. However, drug desensibilisation was effective and allowed to continue treatment with anakinra.

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Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disease mediated by interleukin (IL)-1 production. There are no treatment guidelines for AOSD due to its rarity and heterogenous manifestations. Therefore, each case is challenging and requires a multidisciplinary approach. We report a case of AOSD occurring in pregnant patient who did not respond to standard treatment with glucocorticoids and developed skin reaction to IL-1 receptor antagonist. However, drug desensibilisation was effective and allowed to continue treatment with anakinra.

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Available abstract

Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disease mediated by interleukin (IL)-1 production. There are no treatment guidelines for AOSD due to its rarity and heterogenous manifestations. Therefore, each case is challenging and requires a multidisciplinary approach. We report a case of AOSD occurring in pregnant patient who did not respond to standard treatment with glucocorticoids and developed skin reaction to IL-1 receptor antagonist. However, drug desensibilisation was effective and allowed to continue treatment with anakinra.

Key concepts: Anakinra, Adult-onset Still's disease, Medicine, Disease, Intensive care medicine, Interleukin 1 receptor antagonist, Antagonist, Receptor antagonist

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