2023•IUPHAR/BPS Guide to Pharmacology CITEOpen access

Peptidyl-prolyl cis/trans isomerases in GtoPdb v.2023.1

Stephanie Annett, Tracy Robson

Abstract

Peptidyl-prolyl cis/trans isomerases (PPIases) are an enzyme family which catalyse the cis/trans isomerisation of proline peptide bonds to promote the folding and re-folding of peptides and proteins. Three subfamilies have been identified: cyclophilins, FK506-binding proteins and parvulins. Individual PPIases are overexpressed in a number of cancers [62], and family members have been targetted for immunosuppressant effects.

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Key concepts: FKBP, Isomerase, Prolyl isomerase, Cis-trans-Isomerases, Peptidylprolyl isomerase, Proline, Chemistry, Stereochemistry