2023•Italian Journal of MedicineOpen access

Adult-onset Still’s disease with secondary macrophage activation syndrome: a case report

Giuseppe Nicoletti, Antonio Bonelli, Rocco Clemente, Simona Ciuffreda, Gaetano Dentamaro, Agata Tiziana La Masa, Vito Lascaro, Pasquale Santarcangelo

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Abstract

We describe a case of adult-onset Still’s disease (AOSD) with secondary macrophage activation syndrome. AOSD is a rare disease with unknown origin. Rarely it’s complicated by secondary macrophage activation syndrome, which is a life-threatening disorder. Because the diagnosis of AOSD is essential for exclusion and complications are life-threatening, it is mandatory for a prompt and extensive diagnostic workup and treatment.

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We describe a case of adult-onset Still’s disease (AOSD) with secondary macrophage activation syndrome. AOSD is a rare disease with unknown origin. Rarely it’s complicated by secondary macrophage activation syndrome, which is a life-threatening disorder. Because the diagnosis of AOSD is essential for exclusion and complications are life-threatening, it is mandatory for a prompt and extensive diagnostic workup and treatment.

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Available abstract

We describe a case of adult-onset Still’s disease (AOSD) with secondary macrophage activation syndrome. AOSD is a rare disease with unknown origin. Rarely it’s complicated by secondary macrophage activation syndrome, which is a life-threatening disorder. Because the diagnosis of AOSD is essential for exclusion and complications are life-threatening, it is mandatory for a prompt and extensive diagnostic workup and treatment.

Key concepts: Medicine, Macrophage activation syndrome, Adult-onset Still's disease, Disease, Macrophage, Pediatrics, Immunology, Internal medicine

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