2023•Pharmaceutical ResearchRequires access

Prediction of Omeprazole Pharmacokinetics and its Inhibition on Gastric Acid Secretion in Humans Using Physiologically Based Pharmacokinetic-Pharmacodynamic Model Characterizing CYP2C19 Polymorphisms

Shuai Li, Lei Xie, Yang Lu, Ling Jiang, Yiting Yang, Hao Zhi, Xiaodong Liu, Hanyu Yang, Li Liu

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Key concepts: Physiologically based pharmacokinetic modelling, Omeprazole, Pharmacokinetics, CYP2C19, Pharmacology, Pharmacodynamics, Chemistry, CYP3A4

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Prediction of Omeprazole Pharmacokinetics and its Inhibition on Gastric Acid Secretion in Humans Using Physiologically Based Pharmacokinetic-Pharmacodynamic Model Characterizing CYP2C19 Polymorphisms — Research Paper | ScholarLens