2023•International Journal of Molecular SciencesOpen access

The Role of Autotaxin and LPA Signaling in Embryonic Development, Pathophysiology and Cancer

Christiana Magkrioti, Eleanna Kaffe, Vassilis Aidinis

Abstract

Autotaxin (ATX) or Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) is a secreted enzyme with lysophospholipase D activity, with its primary function being the extracellular hydrolysis of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), a bioactive lipid [...].

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Key concepts: Autotaxin, Lysophosphatidic acid, Lysophosphatidylcholine, Phosphodiesterase, Lysophospholipase, Biochemistry, Extracellular, Chemistry