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2023•Chemistry LettersRequires access

Effect of Hydrophilic Changes in Base Pair Mismatches on Deamination of Cytosine Photo-crosslinked to 3-Cyanovinylcarbazole

Siddhant Sethi, Kanako Ishino, Kai Takeda, Shigetaka Nakamura, Kenzo Fujimoto

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Abstract

In this study, to understand the effects of base-pair mismatch on the deamination of cytosine cross-linked with 3-cyanovinylcarbazole, the complementary base of the target cytosine was changed from guanine (G) to adenine (A), thymine (T), cytosine (C), 5-methylcytosine (mC), and uracil (U). Notably, it was found that the fastest deamination of C to U occurs when C-C mismatching occurs.

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What this paper is about

In this study, to understand the effects of base-pair mismatch on the deamination of cytosine cross-linked with 3-cyanovinylcarbazole, the complementary base of the target cytosine was changed from guanine (G) to adenine (A), thymine (T), cytosine (C), 5-methylcytosine (mC), and uracil (U). Notably, it was found that the fastest deamination of C to U occurs when C-C mismatching occurs.

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Available abstract

In this study, to understand the effects of base-pair mismatch on the deamination of cytosine cross-linked with 3-cyanovinylcarbazole, the complementary base of the target cytosine was changed from guanine (G) to adenine (A), thymine (T), cytosine (C), 5-methylcytosine (mC), and uracil (U). Notably, it was found that the fastest deamination of C to U occurs when C-C mismatching occurs.

Key concepts: Deamination, Cytosine, Chemistry, Uracil, Thymine, Guanine, DNA, Nucleobase

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Effect of Hydrophilic Changes in Base Pair Mismatches on Deamination of Cytosine Photo-crosslinked to 3-Cyanovinylcarbazole — Research Paper | ScholarLens