2023•Emerging infectious diseasesOpen access

Therapeutic Failure and Acquired Bedaquiline and Delamanid Resistance in Treatment of Drug-Resistant TB

James Millard, Stephanie Rimmer, Camus Nimmo, Max R. O’Donnell

Abstract

New classes of antitubercular drugs, diarylquinolines and nitroimidazoles, have been associated with improved outcomes in the treatment of drug-resistant tuberculosis, but that success is threatened by emerging drug resistance. We report a case of bedaquiline and delamanid resistance in a 55-year-old woman in South Africa with extensively drug-resistant tuberculosis and known HIV.

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Key concepts: Bedaquiline, Drug resistance, Medicine, Intensive care medicine, Drug, Extensively drug-resistant tuberculosis, Drug tolerance, Tuberculosis