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2023•British Journal of HaematologyOpen access

What drives CAR‐T emergent cytopenia?

Robert K. Hills

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Abstract

Prolonged cytopenia after CAR-T cell therapy is an acknowledged problem. At present, the causes and implications of prolonged cytopenia are unclear. The paper by Kitamura et al identified that prolonged cytopenia is associated with alterations in the bone marrow niche identified before CAR-T therapy, indicating a potential predictor of this serious side-effect of treatment. Commentary on: Kitamura et al. Bone marrow microenvironment disruption and sustained inflammation with prolonged haematologic toxicity after CAR T-cell therapy? Br J Haematol 2023;202:294-307.

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What this paper is about

Prolonged cytopenia after CAR-T cell therapy is an acknowledged problem. At present, the causes and implications of prolonged cytopenia are unclear. The paper by Kitamura et al identified that prolonged cytopenia is associated with alterations in the bone marrow niche identified before CAR-T therapy, indicating a potential predictor of this serious side-effect of treatment. Commentary on: Kitamura et al. Bone marrow microenvironment disruption and sustained inflammation with prolonged haematologic toxicity after CAR T-cell therapy? Br J Haematol 2023;202:294-307.

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Available abstract

Prolonged cytopenia after CAR-T cell therapy is an acknowledged problem. At present, the causes and implications of prolonged cytopenia are unclear. The paper by Kitamura et al identified that prolonged cytopenia is associated with alterations in the bone marrow niche identified before CAR-T therapy, indicating a potential predictor of this serious side-effect of treatment. Commentary on: Kitamura et al. Bone marrow microenvironment disruption and sustained inflammation with prolonged haematologic toxicity after CAR T-cell therapy? Br J Haematol 2023;202:294-307.

Key concepts: Cytopenia, Bone marrow, Medicine, Internal medicine, Cancer research, Immunology

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