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2023•Unpublished venueOpen access

Supplementary Fig. S1 from Hypoxia Causes Downregulation of Dicer in Hepatocellular Carcinoma, Which Is Required for Upregulation of Hypoxia-Inducible Factor 1α and Epithelial–Mesenchymal Transition

Ahmed Atef Ibrahim, Christian Schmithals, Erik Kowarz, Verena Köberle, Bianca Kakoschky, Thomas Pleli, Otto Kollmar, Scarlett Nitsch, Oliver Waidmann, Fabian Finkelmeier, Stefan Zeuzem, Horst‐Werner Korf, Tobias Schmid, Andreas Weigert, Bernd Kronenberger, Rolf Marschalek, Albrecht Piiper

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Abstract

Supplementary Fig. S1. Apoptosis is not responsible for down-regulation of Dicer in HepG2 under hypoxic conditions. Western blot analysis of protein extracts from HepG2 cells cultured for 24 h under hypoxia (1% O2) (H) or normoxia (N) using anti-cleaved caspase-3 antibody. For positive control, HepG2 cells were treated with BI 2536 for 48 h with the indicated concentrations.

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What this paper is about

Supplementary Fig. S1. Apoptosis is not responsible for down-regulation of Dicer in HepG2 under hypoxic conditions. Western blot analysis of protein extracts from HepG2 cells cultured for 24 h under hypoxia (1% O2) (H) or normoxia (N) using anti-cleaved caspase-3 antibody. For positive control, HepG2 cells were treated with BI 2536 for 48 h with the indicated concentrations.

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Available abstract

Supplementary Fig. S1. Apoptosis is not responsible for down-regulation of Dicer in HepG2 under hypoxic conditions. Western blot analysis of protein extracts from HepG2 cells cultured for 24 h under hypoxia (1% O2) (H) or normoxia (N) using anti-cleaved caspase-3 antibody. For positive control, HepG2 cells were treated with BI 2536 for 48 h with the indicated concentrations.

Key concepts: Downregulation and upregulation, Hypoxia (environmental), Dicer, Western blot, Hepatocellular carcinoma, Apoptosis, Chemistry, Hypoxia-inducible factors

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Supplementary Fig. S1 from Hypoxia Causes Downregulation of Dicer in Hepatocellular Carcinoma, Which Is Required for Upregulation of Hypoxia-Inducible Factor 1α and Epithelial–Mesenchymal Transition — Research Paper | ScholarLens