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2023•Unpublished venueOpen access

Supplementary Figure S6: Ipilimumab does not deplete CD4+CTLA-4+FOXP3+ Tregs from Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers

Anu Sharma, Sumit K. Subudhi, Jorge Blando, Jorge Scutti, Luis M. Vence, Jennifer A. Wargo, James P. Allison, Antoni Ribas, Padmanee Sharma

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Abstract

Tumor infiltrating cells from paired melanoma tissue (N=5 pre-Ipi; N=5 post-Ipi) were analyzed by CyTOF. The impact of ipilimumab on the intratumoral frequency of A) CD3+CD4+FOXP3+CTLA-4+ (Tregs), B) CD3+CD4+FOXP3-CTLA-4+ T cells, and C) CD3+CD4+FOXP3-CTLA-4- T cells. The dot plots represent mean with SD, and each dot represents a patient. Statistical significance is defined as P< 0.05.

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What this paper is about

Tumor infiltrating cells from paired melanoma tissue (N=5 pre-Ipi; N=5 post-Ipi) were analyzed by CyTOF. The impact of ipilimumab on the intratumoral frequency of A) CD3+CD4+FOXP3+CTLA-4+ (Tregs), B) CD3+CD4+FOXP3-CTLA-4+ T cells, and C) CD3+CD4+FOXP3-CTLA-4- T cells. The dot plots represent mean with SD, and each dot represents a patient. Statistical significance is defined as P< 0.05.

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Available abstract

Tumor infiltrating cells from paired melanoma tissue (N=5 pre-Ipi; N=5 post-Ipi) were analyzed by CyTOF. The impact of ipilimumab on the intratumoral frequency of A) CD3+CD4+FOXP3+CTLA-4+ (Tregs), B) CD3+CD4+FOXP3-CTLA-4+ T cells, and C) CD3+CD4+FOXP3-CTLA-4- T cells. The dot plots represent mean with SD, and each dot represents a patient. Statistical significance is defined as P< 0.05.

Key concepts: FOXP3, Ipilimumab, CTLA-4, CD3, Immunology, Immunotherapy, Melanoma, Regulatory T cell

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Supplementary Figure S6: Ipilimumab does not deplete CD4+CTLA-4+FOXP3+ Tregs from Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers — Research Paper | ScholarLens