2023•European Journal of Organic ChemistryRequires access

Metal‐ and Catalyst‐Free Synthesis of 2‐Substituted‐Phthalimides Using 2‐(Arenesulfonyl)Phthalimide as Key Reagents

Abdalrahman Khalifa, Marco D. Giles, Hamed I. Ali, Samy Mohamady

Abstract

Abstract Phthalimide derivatives are important in medicinal chemistry, several phthalimidation methodologies have been developed. Here, we report a facile, metal‐free, and catalyst‐free method for the preparation of N‐phthalimides in good to excellent yield by reacting 2‐(arenesulfonyl)phthalimides with various amine substrates.

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Key concepts: Phthalimides, Phthalimide, Chemistry, Catalysis, Reagent, Yield (engineering), Amine gas treating, Metal