2002•Medical Entomology and ZoologyRequires access

From laboratory to clinical practice

Slobodan Vukičević, Kuber T. Sampath

Abstract

Biochemistry of bone morphogenetic proteins.- Prostate-derived factor and growth and differentiation factor-8:newly discovered members of the TGF-? superfamily.- Bone morphogenetic protein receptors and their nuclear effectorsin bone formation.- Deciphering the binding code of BMP-receptor interaction.- Biology of bone morphogenetic proteins.- Preclinical models of recombinant BMP induced healingof orthopedic defects.- Osteogenic protein-1 (OP-1, BMP-7) for stimulation of healingof closed fractures: evidence based medicine and pre-clinical experience.- Maxillofacial reconstruction.- Bone morphogenetic proteins in periodontal regeneration.- Osteogenic protein-1 (OP-1) in the repair of bone defects and fracturesof long bones: clinical experience.- Evaluation of OP-1 in a rabbit model of lumbar fusions.- Bone morphogenetic proteins and the synovial joints.- BMPs in articular cartilage repair.- The role of bone morphogenetic proteins in kidney development and repair.- Effects of bone morphogenetic proteins on neural tissues.

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Available abstract

Key concepts: Bone morphogenetic protein, Bone morphogenetic protein 5, Bone morphogenetic protein 7, Bone morphogenetic protein 8A, Bone morphogenetic protein 6, Bone morphogenetic protein 2, Bone healing, Cell biology