2023•Microbiology SpectrumOpen access

BysR, a LysR-Type Pleiotropic Regulator, Controls Production of Occidiofungin by Activating the LuxR-Type Transcriptional Regulator AmbR1 in Burkholderia sp. Strain JP2-270

Lijuan Wu, Liqun Tang, Yuchang He, Cong Han, Lei Wang, Yunzeng Zhang, E Zhiguo

Abstract

We report for the first time that occidiofungin production is regulated by the global transcriptional factor BysR, by directly targeting the specific regulator ambR1 , which further promotes the transcription of ocf genes. BysR also acts as a pleiotropic regulator that controls various cellular processes in Burkholderia sp. strain JP2-270.

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Key concepts: Regulator, Burkholderia, Biology, Transcriptional regulation, Overproduction, Genetics, Gene, Transcription factor