2023mBioOpen access

Advances and Breakthroughs in IRES-Directed Translation and Replication of Picornaviruses

Sahibzada Waheed Abdullah, Jin’en Wu, Xuefei Wang, Huichen Guo, Shiqi Sun

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Abstract

, past and present discoveries regarding ITAFs, and their mechanism of action. The herbal extracts, drugs, and chemicals, which indicated their importance in controlling viruses, were also summarized. In addition, we discussed the movement of ITAFs from the nucleus to viral replication factories. We believe this review will stimulate researchers to search for more novel ITAFs, drugs, herbal extracts, and chemicals, enhancing the understanding of virus-host interaction.

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What this paper is about

, past and present discoveries regarding ITAFs, and their mechanism of action. The herbal extracts, drugs, and chemicals, which indicated their importance in controlling viruses, were also summarized. In addition, we discussed the movement of ITAFs from the nucleus to viral replication factories. We believe this review will stimulate researchers to search for more novel ITAFs, drugs, herbal extracts, and chemicals, enhancing the understanding of virus-host interaction.

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OpenAlex reports 54 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

, past and present discoveries regarding ITAFs, and their mechanism of action. The herbal extracts, drugs, and chemicals, which indicated their importance in controlling viruses, were also summarized. In addition, we discussed the movement of ITAFs from the nucleus to viral replication factories. We believe this review will stimulate researchers to search for more novel ITAFs, drugs, herbal extracts, and chemicals, enhancing the understanding of virus-host interaction.

Key concepts: Internal ribosome entry site, Picornavirus, Picornaviridae, Biology, Translation (biology), Virology, Eukaryotic translation, Viral replication

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