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2023•Archives of Medical ScienceOpen access

The emerging role of ferroptosis in myocardial fibrosis of atrial fibrillation

Honghua Yue, Yujia Zhan, Zheng Zhang, Weitao Liang, Zhong Wu

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Abstract

Introduction: The aim of this study was to investigate the relationship between ferroptosis and myocardial fibrosis in atrial fibrillation (AF). Methods: The patient's left atrial appendage tissue was obtained in cardiac surgery. Sirius red staining, Prussian blue and Western blot were used to detect staining to assess histological fibrosis and ferroptosis changes. Results: = 0.0004). The key proteins related to the regulation of ferroptosis were significantly abnormal in the AF group. Conclusions: Ferroptosis is involved in myocardial fibrosis of AF and is a potential target for the diagnosis, prevention and treatment of AF.

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What this paper is about

Introduction: The aim of this study was to investigate the relationship between ferroptosis and myocardial fibrosis in atrial fibrillation (AF). Methods: The patient's left atrial appendage tissue was obtained in cardiac surgery. Sirius red staining, Prussian blue and Western blot were used to detect staining to assess histological fibrosis and ferroptosis changes. Results: = 0.0004). The key proteins related to the regulation of ferroptosis were significantly abnormal in the AF group. Conclusions: Ferroptosis is involved in myocardial fibrosis of AF and is a potential target for the diagnosis, prevention and treatment of AF.

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Available abstract

Introduction: The aim of this study was to investigate the relationship between ferroptosis and myocardial fibrosis in atrial fibrillation (AF). Methods: The patient's left atrial appendage tissue was obtained in cardiac surgery. Sirius red staining, Prussian blue and Western blot were used to detect staining to assess histological fibrosis and ferroptosis changes. Results: = 0.0004). The key proteins related to the regulation of ferroptosis were significantly abnormal in the AF group. Conclusions: Ferroptosis is involved in myocardial fibrosis of AF and is a potential target for the diagnosis, prevention and treatment of AF.

Key concepts: Medicine, Sirius Red, Atrial fibrillation, Fibrosis, Myocardial fibrosis, Staining, Cardiology, Internal medicine

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