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2023•JAAD Case ReportsOpen access

A case of bullous lesions in cutaneous T-cell lymphoma

Suzanne Xu, Emma Weiss, Katelyn Singh, William Damsky, Michael Girardi

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Abstract

Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL), is characterized by erythematous patches and/or plaques with epidermotropic malignant lymphocytes.1 Sézary syndrome (SS) is a leukemic form of CTCL that manifests with erythroderma, generalized lymphadenopathy, and a clonal population of T cells in the skin, peripheral blood, and lymph nodes. While most cases of SS arise de novo, MF may also progress to erythroderma and leukemia. The appearance of bullous lesions in both MF and SS subtypes of CTCL is uncommon and portends a markedly worse prognosis.

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What this paper is about

Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL), is characterized by erythematous patches and/or plaques with epidermotropic malignant lymphocytes.1 Sézary syndrome (SS) is a leukemic form of CTCL that manifests with erythroderma, generalized lymphadenopathy, and a clonal population of T cells in the skin, peripheral blood, and lymph nodes. While most cases of SS arise de novo, MF may also progress to erythroderma and leukemia. The appearance of bullous lesions in both MF and SS subtypes of CTCL is uncommon and portends a markedly worse prognosis.

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Available abstract

Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL), is characterized by erythematous patches and/or plaques with epidermotropic malignant lymphocytes.1 Sézary syndrome (SS) is a leukemic form of CTCL that manifests with erythroderma, generalized lymphadenopathy, and a clonal population of T cells in the skin, peripheral blood, and lymph nodes. While most cases of SS arise de novo, MF may also progress to erythroderma and leukemia. The appearance of bullous lesions in both MF and SS subtypes of CTCL is uncommon and portends a markedly worse prognosis.

Key concepts: Erythroderma, Mycosis fungoides, Medicine, Cutaneous T-cell lymphoma, Lymphoma, Dermatology, Atypical Lymphocyte, Pathology

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