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2023•Antimicrobial Agents and ChemotherapyOpen access

Molecular Markers of Sulfadoxine-Pyrimethamine Resistance in Samples from Children with Uncomplicated Plasmodium falciparum at Three Sites in Angola in 2019

Stefano Rosillo, Pedro Rafael Dimbu, Ana Luísa Micolo Cândido, Je-Hoon Michael Oh, Carolina Miguel Ferreira, Benjamin Nieto Andrade, Sarah M. Labuda, Roberta Horth, Julia Kelley, Joana Morais, Filomeno Fortes, José Franco Martins, Eldin Talundzic, Mateusz M. Pluciński

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Abstract

Sulfadoxine-pyrimethamine (SP) is used for prevention of malaria in pregnant women in Angola. We sequenced the Plasmodium falciparum dihydrofolate reductase ( pfdhfr ) and dihydropteroate synthase ( pfdhps ) genes, implicated in SP resistance, in samples collected during a 2019 study of artemisinin-based combination therapy efficacy in Benguela, Lunda Sul, and Zaire provinces.

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What this paper is about

Sulfadoxine-pyrimethamine (SP) is used for prevention of malaria in pregnant women in Angola. We sequenced the Plasmodium falciparum dihydrofolate reductase ( pfdhfr ) and dihydropteroate synthase ( pfdhps ) genes, implicated in SP resistance, in samples collected during a 2019 study of artemisinin-based combination therapy efficacy in Benguela, Lunda Sul, and Zaire provinces.

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Available abstract

Sulfadoxine-pyrimethamine (SP) is used for prevention of malaria in pregnant women in Angola. We sequenced the Plasmodium falciparum dihydrofolate reductase ( pfdhfr ) and dihydropteroate synthase ( pfdhps ) genes, implicated in SP resistance, in samples collected during a 2019 study of artemisinin-based combination therapy efficacy in Benguela, Lunda Sul, and Zaire provinces.

Key concepts: Dihydropteroate synthase, Sulfadoxine/pyrimethamine, Plasmodium falciparum, Sulfadoxine, Malaria, Dihydrofolate reductase, Artemisinin, Pyrimethamine

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