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2023•GastroenterologyOpen access

A “Two-in-One Hit” Model of Shortcut Carcinogenesis in MLH1 Lynch Syndrome Carriers

Aysel Ahadova, Albrecht Stenzinger, Toni T. Seppälä, Robert Hüneburg, Matthias Kloor, Hendrik Bläker, Jan-Niklas Wittemann, Volker Endris, Leonie Gerling, Veit Bertram, Marie Theres Neumuth, Johannes Witt, Sebastián Graf, Glen Kristiansen, Oliver Hommerding, Saskia Haupt, Alexander Zeilmann, Vincent Heuveline, Daniel Kazdal, Johannes Gebert, Magnus von Knebel Doeberitz, Jukka‐Pekka Mecklin, Jacob Nattermann

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Key concepts: PMS2, Lynch syndrome, MSH6, MLH1, MSH2, DNA mismatch repair, Genetics, Germline mutation

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