2023•Seven Editora eBooksOpen access
Mutation Profile And Tarv Resistance In People Living With Hiv Submitted To Genotyping Test In A Reference Laboratory In Belém Do Pará, Brazil
Alexandre Augusto Bentaberry-Rosa, Aline Cecy Rocha de Lima, Maria Amélia de Oliveira da Costa, Rubens Einar Corrêa Dantas, Andrea Nazaré Monteiro Rangel da Silva, Jacqueline Cortinhas Monteiro, Rogério Valois Laurentino, Rosimar Neris Martins Feitosa
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Abstract
To describe the presence of mutations and the ART resistance profile in PLHIV in Belém, Pará. Methods: This is a cross-sectional, descriptive and retrospective study, where 189 genotyping reports of individuals were included, regardless of age or sex and who were seen in the period from 2013 to 2015. Results: Most individuals had a high viral load (93%), low TCD4+ lymphocyte levels (97%) and the most prevalent HIV subtype was B (78%). We observed in this study a high presence of mutations in all classes of drugs used in ART with emphasis on M184V (ITRNN), K103N (ITRNN) and L63A/P/T/Q (PI), demonstrating that many mutations can contribute to the profile of viral resistance. Conclusion: The results presented show the importance of genotyping testing not only for choosing therapeutic and surveillance regimens, but also to contribute to patient adherence to antiretroviral treatment.
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