Neuroprotective Effect of Neuroglobin in Simultaneous Incomplete Ischemia

The role of neuroglobin in ischemia has not been studied in detail. A number of studies indicate its neuroprotective effect, other data refute its importance for the survival of neurons in conditions of lack of oxygen. In the course of the conducted studies, the neuroprotective role of neurooglobin in certain types of cerebral ischemia has been established. The results obtained resolve the contradiction noted in the literature data about the role of neuroglobin in the pathogenesis of cerebral ischemia and show that in certain models of cerebral ischemia, with sufficient time to implement compensatory mechanisms, neuroglobin participates in neuroprotection, while in forms of cerebral ischemia, where this time is insufficient, its content decreases and there is no neuroprotective effect.