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2022•Therapeutic Drug MonitoringOpen access

Subtherapeutic Exposure of Ganciclovir in Children Despite Appropriate Dosing: A Short Communication

Sjanene Marfil, Anne‐Grete Märtson, Marlous Toren-Wielema, Coretta van Leer-Buter, Elisabeth H. Schölvinck, Jan‐Willem C. Alffenaar, Daan J. Touw, Marieke G. G. Sturkenboom

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Abstract

ABSTRACT: Therapeutic drug monitoring (TDM) results for ganciclovir in 12 different treatment episodes showed large intraindividual and interindividual variabilities in the trough concentration and area under the 24-hour concentration-time curve (AUC24). Despite adequate valganciclovir dosing, subtherapeutic concentrations were found in 30% of the treatment episodes. A decrease in viral load was observed regardless of subtherapeutic exposure. These findings show the need for target concentration evaluation and assessment of the applicability of ganciclovir TDM in children.

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What this paper is about

ABSTRACT: Therapeutic drug monitoring (TDM) results for ganciclovir in 12 different treatment episodes showed large intraindividual and interindividual variabilities in the trough concentration and area under the 24-hour concentration-time curve (AUC24). Despite adequate valganciclovir dosing, subtherapeutic concentrations were found in 30% of the treatment episodes. A decrease in viral load was observed regardless of subtherapeutic exposure. These findings show the need for target concentration evaluation and assessment of the applicability of ganciclovir TDM in children.

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Available abstract

ABSTRACT: Therapeutic drug monitoring (TDM) results for ganciclovir in 12 different treatment episodes showed large intraindividual and interindividual variabilities in the trough concentration and area under the 24-hour concentration-time curve (AUC24). Despite adequate valganciclovir dosing, subtherapeutic concentrations were found in 30% of the treatment episodes. A decrease in viral load was observed regardless of subtherapeutic exposure. These findings show the need for target concentration evaluation and assessment of the applicability of ganciclovir TDM in children.

Key concepts: Dosing, Therapeutic drug monitoring, Ganciclovir, Valganciclovir, Medicine, Trough level, Serum concentration, Trough Concentration

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