2022•Royal Society of Chemistry eBooksRequires access
Alkylation
Author information unavailable
Open publisher page 0 citations
Abstract
Alkylation is the transfer of an alkyl group (CnH2n+1) from one molecule (alkylating agent) to another where it can attach typically to carbon (C-alkylation), but also to oxygen (O-alkylation), nitrogen (N-alkylation), sulfur (S-alkylation) and phosphorous (P-alkylation) depending on the reaction conditions. This chapter discusses the importance of alkylation reactions, then looks at green improvements made by using solid acid catalysts, ionic liquids in Friedel–Crafts reactions, the atom economic borrowing hydrogen strategy and directed alkylation of C–H bonds using alkenes.