2023•Journal of VirologyOpen access

Deletion of African Swine Fever Virus (ASFV) H240R Gene Attenuates the Virulence of ASFV by Enhancing NLRP3-Mediated Inflammatory Responses

Li Huang, Hongyang Liu, Guangqiang Ye, Xiaohong Liu, Weiye Chen, Zilong Wang, Dongming Zhao, Zhaoxia Zhang, Chunying Feng, Liang Hu, Huibin Yu, Shijun Zhou, Xianfeng Zhang, Xijun He, Jun Zheng, Zhigao Bu, Jiangnan Li, Changjiang Weng

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Abstract

African swine fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious and acute hemorrhagic viral disease of domestic pigs, with a high mortality approaching 100%. ASFV has spread rapidly worldwide and caused huge economic losses and ecological consequences.

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Key concepts: African swine fever virus, Biology, African swine fever, Virology, Virulence, Virus, Gene, Disease