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2023•Eurasian Journal of MedicineOpen access

Intermittent Subcutaneous Injections of Apomorphine in Parkinson’s Disease

Mustafa Ceylan, Murat Gültekin, Nazlı Durmaz Çelik, Bedia Marangozoğlu Samancı, Gül Yalçın Çakmaklı, Rezzak Yılmaz

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Abstract

The intermittent subcutaneous injection of apomorphine is highly effective in the management of motor and non-motor symptoms of Parkinson’s disease. Although it has been shown that apomorphine injection can be safely used in selected cases at all stages of the disease, there is no consensus regarding intermittent administration strategies. This review aimed to discuss the indications for intermittent subcutaneous apomorphine use in clinical practice, possible side effects and their management, and contraindicated cases in light of the literature and to present practical recommendations for clinical practice. Cite this article as: Ceylan M, Gültekin M, Durmaz Çelik N, Samanci B, Yalçin Çakmakli G, Yilmaz R. The role and use of intermittent subcutaneous injections of apomorphine in Parkinson’s disease. Eurasian J Med., 2022;54(Suppl. 1):S71-S76.

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What this paper is about

The intermittent subcutaneous injection of apomorphine is highly effective in the management of motor and non-motor symptoms of Parkinson’s disease. Although it has been shown that apomorphine injection can be safely used in selected cases at all stages of the disease, there is no consensus regarding intermittent administration strategies. This review aimed to discuss the indications for intermittent subcutaneous apomorphine use in clinical practice, possible side effects and their management, and contraindicated cases in light of the literature and to present practical recommendations for clinical practice. Cite this article as: Ceylan M, Gültekin M, Durmaz Çelik N, Samanci B, Yalçin Çakmakli G, Yilmaz R. The role and use of intermittent subcutaneous injections of apomorphine in Parkinson’s disease. Eurasian J Med., 2022;54(Suppl. 1):S71-S76.

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Available abstract

The intermittent subcutaneous injection of apomorphine is highly effective in the management of motor and non-motor symptoms of Parkinson’s disease. Although it has been shown that apomorphine injection can be safely used in selected cases at all stages of the disease, there is no consensus regarding intermittent administration strategies. This review aimed to discuss the indications for intermittent subcutaneous apomorphine use in clinical practice, possible side effects and their management, and contraindicated cases in light of the literature and to present practical recommendations for clinical practice. Cite this article as: Ceylan M, Gültekin M, Durmaz Çelik N, Samanci B, Yalçin Çakmakli G, Yilmaz R. The role and use of intermittent subcutaneous injections of apomorphine in Parkinson’s disease. Eurasian J Med., 2022;54(Suppl. 1):S71-S76.

Key concepts: Apomorphine, Medicine, Subcutaneous injection, Parkinson's disease, Disease, Anesthesia, Clinical Practice, Intensive care medicine

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