The efficacy and safety of butylphthalide combined with donepezil in the treatment of vascular dementia: A meta-analysis

Review question / Objective: The efficacy and safety of butylphthalide combined with donepezil in the treatment of vascular dementia: Ameta-analysis. Condition being studied: Vascular dementia is the second most common cause of dementia and a major health concern worldwide, only after to Alzheimer's disease. As the increasing aging of the global population, the number of vascular dementia patients is expected to increase year by year, which will bring great economic burden to all countries in the world. In recent years, more and more published RCT studies have shown that butylphthalide can further improve behavioral ability and dementia symptoms in vascular dementia patients based on donepezil treatment. Our study aimed to systematically evaluate the efficacy and safety of butylphthalide combined with donepezil in the treatment of vascular dementia through meta-analysis, providing an objective and scientific reference for the clinical use of butylphthalide.