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2023•Journal of Labelled Compounds and RadiopharmaceuticalsOpen access

An optimized radiosynthesis of [18F]DK222, a PET radiotracer for imaging PD‐L1

Daniel P. Holt, Dhiraj Kumar, Sridhar Nimmagadda, Robert F. Dannals

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Abstract

F]DK222, a peptide binder of programmed death ligand 1 protein, suitable for human PET studies is described, and results from validation productions are presented. The high specific activity radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice (cGMP) requirements. In addition, the production is extended to use a commercial synthesizer platform (General Electric FASTlab 2).

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F]DK222, a peptide binder of programmed death ligand 1 protein, suitable for human PET studies is described, and results from validation productions are presented. The high specific activity radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice (cGMP) requirements. In addition, the production is extended to use a commercial synthesizer platform (General Electric FASTlab 2).

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Available abstract

F]DK222, a peptide binder of programmed death ligand 1 protein, suitable for human PET studies is described, and results from validation productions are presented. The high specific activity radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice (cGMP) requirements. In addition, the production is extended to use a commercial synthesizer platform (General Electric FASTlab 2).

Key concepts: Radiosynthesis, Pet imaging, Radiochemistry, Specific activity, Chemistry, Nuclear chemistry, Nuclear medicine, Positron emission tomography

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