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1966•The Journal of ImmunologyRequires access

Antibody Formation

Martin S. Finkelstein, Jonathan W. Uhr

Open publisher page 23 citations

Abstract

Summary Avidity of guinea pig antibodies to bacteriophage φX 174 was studied by means of the decision-tube and reactivation methods of Jerne and Avegno. The avidity of both γM and γG antibodies increased with time after immunization. γM antibody obtained 1 week after immunization usually had a higher avidity than γG antibody obtained 2 weeks after immunization. The possibility that the relatively high avidity of γM antibody is caused by multiple binding between a single phage particle and one γM antibody molecule is discussed.

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What this paper is about

Summary Avidity of guinea pig antibodies to bacteriophage φX 174 was studied by means of the decision-tube and reactivation methods of Jerne and Avegno. The avidity of both γM and γG antibodies increased with time after immunization. γM antibody obtained 1 week after immunization usually had a higher avidity than γG antibody obtained 2 weeks after immunization. The possibility that the relatively high avidity of γM antibody is caused by multiple binding between a single phage particle and one γM antibody molecule is discussed.

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Available abstract

Summary Avidity of guinea pig antibodies to bacteriophage φX 174 was studied by means of the decision-tube and reactivation methods of Jerne and Avegno. The avidity of both γM and γG antibodies increased with time after immunization. γM antibody obtained 1 week after immunization usually had a higher avidity than γG antibody obtained 2 weeks after immunization. The possibility that the relatively high avidity of γM antibody is caused by multiple binding between a single phage particle and one γM antibody molecule is discussed.

Key concepts: Avidity, Antibody, Immunization, Virology, Guinea pig, Antigen, Biology, Molecular biology

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