2022•Smart MedicineOpen access

Front Cover: Reprogramming Stem Cells in Regenerative Medicine (Smart Medicine 1/2022)

Jiayi Mao, Qimanguli Saiding, Shutong Qian, Zhimo Liu, Binfan Zhao, Qiuyu Zhao, Bolun Lu, Xiyuan Mao, Liucheng Zhang, Yuguang Zhang, Xiaoming Sun, Wenguo Cui

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Abstract

Induced pluripotent stem cells (iPSC) that are generated from adult somatic cells are induced to express genes that make them pluripotent through reprogramming techniques, which may open up new possibilities for regenerative medicine to treat diseases in the future. Biotechnological, chemical, and physical modulation techniques are different reprogramming cell technologies to obtain iPSC and present their respective strengths in iPSC reprogramming-based regenerative therapies, such as hair follicle defects, myocardial infarction, neurological disorders, liver diseases, and spinal cord injuries.

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Key concepts: Reprogramming, Induced pluripotent stem cell, Regenerative medicine, Germ layer, Somatic cell, Stem cell, Neuroscience, Regeneration (biology)