2022•New Journal of ChemistryRequires access

Electrochemically promoted annulation of aldehydes and carbazates: access to 2-alkoxy/aryloxy-5-substituted 1,3,4-oxadiazole and 1,3,4-oxadiazol-2(3 H )-one derivatives

Hongjun Li, Dong Tang, Zafar Iqbal, Yaya Wan, Rui Jiang, Zhixiang Yang, Jinhui Yang

Abstract

An efficient and eco-friendly electrosynthesis of 2-alkoxy/aryloxy-5-substituted 1,3,4-oxadiazoles, and 5-substituted 1,3,4-oxadiazol-2(3 H )-ones has been developed through the annulation of aldehydes and carbazates.

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Key concepts: Chemistry, Annulation, Oxadiazole, Alkoxy group, Medicinal chemistry, Combinatorial chemistry, Stereochemistry, Organic chemistry