An apolipoprotein e synthetic peptide targets lipid particles to lipoprotein receptors

Abstract: An apolipoprotein E 139-158 synthetic peptide was tested for targeting lipid particles to lipoprotein receptors. It was shown that this peptide increases lipid particle binding followed by receptor-mediated endocytosis by cells. In addition, the peptide mediates both acute clearance of lipoproteins followed by the decrease of cholesterol level in a rat blood and acute uptake of liposomes by the tissues which have a high level expression of lipoprotein receptors.