The Role of IL-18 and Human Cytomegalovirus in Type 1 Diabetes Mellitus in Thi-Qar Province

Previous studies indicated that elevated serum levels of Interleukin -18 (IL-18) and human cytomegalovirus (HCMV) antibodies have a fundamental role in the pathogenesis of Type I diabetic mellitus T1DM. Therefore, the aim of the current study was to investigate the possible overlap between human cytomegalovirus (HCMV) and Interleukin-18 (IL-18) with the pathogenesis of T1DM. The serum of (45) T1DM patients and (45) healthy controls were used to detect IL-18 levels with an ELISA Kit and detect HCMV with cobas c411 apparatus for detect IgM and IgG HCMV. The results showed that the levels of IL-18 and human CMV IgM, IgG were significantly higher in patients with type 1 diabetes compared to the control group (45.8773 ±12.196 and 0.52 ± 0.25, 63.52 ±13.0 pg/ml for patients respectively) versus (12.611 ±3.9 and 0.11 ±0.01, 0.261 ±0.68 pg/ml for healthy subjects, respectively); The values were ​​at P value ≤ 0.05. The results of the data concluded that there was a significant increase of IL-18 and human CMV IgM, IgG in the serum of the patient group compared to the lower levels in the control group, indicating that these markers may be involved in the pathogenesis and development of T. These data concluded that there was a significant increase in serum IL-18 and HCMV Abs, compared to the lower levels in the control group, indicating that these markers may be involved in the pathogenesis and development of T1DM.