2022•SclerosisOpen access

Anti-Yo Paraneoplastic Cerebellar Degeneration and Breast Cancer: A Long Survival of Persistent Cerebellar Syndrome

Gianluca Avino, Fabiola De Marchi, Roberto M. Cantello, Letizia Mazzini

Abstract

Paraneoplastic neurological syndromes (PNS) occur in 1–3% of all cancer patients with several cancer-related neurologic diseases involving any part of the nervous system. Paraneoplastic cerebellar degeneration (PCD) is a specific type of PNS characterized by sub-acute cerebellar syndrome with trunk and limb ataxia, dysarthria, diplopia, and vertigo. We report herein the case of a 70-year-old female patient with cerebellar symptoms and transient anti-Yo antibody PCD positivity manifested three years after a breast cancer diagnosis who is currently neurologically stable after an extended follow-up.

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Key concepts: Paraneoplastic cerebellar degeneration, Cerebellar Degeneration, Medicine, Dysarthria, Cerebellar ataxia, Vertigo, Ataxia, Diplopia