Serious Cardiovascular Adverse Event Associated with Hydroxychloroquine with Azithromycin in Patient with COVID-19 : A Pharmacovigilance Analysis of the FDA Adverse Event Reporting System (FAERS)

The use of Hydroxychloroquine combine with Azythromycin for the treatment of coronavirus disease (COVID-19) it may increases the risk of serious cardiovascular advere events. WHO not recommended for the use of HCQ to treat the COVID-19 because it has serious side effect on heart like Arrhythmia ,cardiac toxicity. In the following describe the risk of serious cardiovascular adverse event using HCQ is combined with Azythromycin it compared with that therapeutic alternatives. Some clinical trial that reporting the combine of HCQ with AZ demonstrated better efficacy than signal drug combination of HCQ and AZ has synergestic effect against viral infectious. The FAERS that evaluate adverse effect reports ,medication error reports and product quality complaint resulting in adverse effect that were submitted to FDA. The performing the test to analysis to case series using the US FDA Adverse Event Reporting System(FAERS).