2022•mBioOpen access

A Persistent Tuberculosis Outbreak in the UK Is Characterized by Hydrophobic fadB4 -Deficient Mycobacterium tuberculosis That Replicates Rapidly in Macrophages

Robeena Farzand, Richard Haigh, Philip Monk, Pranabashis Haldar, Hemu Patel, Manish Pareek, Raman Verma, Michael R. Barer, Gerrit Woltmann, Lauren Ahyow, Heena Jagatia, Jonathan Decker, Galina V. Mukamolova, Andrea May Cooper, Natalie J. Garton, Helen M. O’Hare

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Abstract

Tuberculosis (TB) killed 1.5 million people in 2020 and affects every country. The extent to which the natural genetic diversity of Mycobacterium tuberculosis influences disease manifestation at both the individual and epidemiological levels remains poorly understood.

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Key concepts: Tuberculosis, Mycobacterium tuberculosis, Outbreak, Disease, Immunology, Epidemiology, Medicine, Virology