Untitled research work

The ototoxicity and nephrotoxicity of netilmicin were compared with those of dibekacin, kanamycin and amikacin. Groups of five rabbits each were given doses of 50 or 100mg/kg of either one of the four drugs for 30 days. Ten days after the last injection, all animals were prepared for histopathological studies of inner ears and kidneys. Histological results of inner ears obtained by the rabbit show the least ototoxicity of netilmicin in comparison to the other three aminoglycoside antibiotics. No significant differences were observed among the nephrotoxicity of netilmicin and dibekacin or amikacin.